UK Prospective Diabetes Study
I am giving this information and link, because UKPDS is mentioned in some of the usmleworld questions for step 2 CK. One of the questions is about the use of ACE inhibitors to slow down the progression of renal damage in patients with diabetes mellitus with or without hypertension. Microalbuminuria is used as a sensitive marker of renal microvascular damage. Simply put, every patient with DM and microalbuminuria should be on ACE inhibitors.
UKPDS has shown that the risk of microvascular complications in diabetics can be reduced with tight blood glucose control as well as tight blood pressure control.
The UK Prospective Diabetes Study was a 20-year trial which recruited 5,102 patients with type 2 diabetes in 23 clinical centres based in England, Northern Ireland and Scotland. The study was led by the late Professor Robert Turner, Professor of Medicine, and Professor Rury Holman, Professor of Diabetic Medicine at the University of Oxford. The major results were presented at the September 1998 EASD meeting in Barcelona, published simultaneously in five papers in the Lancet and the British Medical Journal and released as a set of 100 slides that can be downloaded or viewed on screen. Read more>>>