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Low-Dose Estrogen and Venlafaxine Similarly Effective for Menopausal Symptoms

May 31, 2014

Low-dose estradiol and venlafaxine are both effective treatments for vasomotor symptoms in menopausal women, a JAMA Internal Medicine study finds.

Some 340 peri- or postmenopausal women with bothersome vasomotor symptoms (hot flashes, night sweats) were randomized to receive low-dose estradiol (0.5 mg/day), low-dose venlafaxine (a serotonin-norepinephrine reuptake inhibitor; 75 mg/day), or placebo daily for 8 weeks.

Symptom frequency was reduced significantly more with estradiol (by 53%) and with venlafaxine (48%) than with placebo (29%). Both active treatments were well tolerated, although estradiol was more often associated with abnormal vaginal bleeding and venlafaxine with blood pressure increases.

The researchers note that “while the efficacy of low-dose estradiol may be slightly superior to that of venlafaxine, the difference is small and of uncertain clinical relevance.” They conclude: “Treatment decisions should weigh the risk profile of each agent for each individual woman, taking into account her risk factor status and personal preferences regarding treatment options.”

See more at: http://www.jwatch.org/fw108875/2014/05/27/low-dose-estrogen-and-venlafaxine-similarly-effective#sthash.6Pz6evr6.dpuf

Low-Dose Estrogen and Venlafaxine Similarly Effective for Menopausal Symptoms — Physician’s First Watch.

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